(070) Testosterone Therapy in Men with Klinefelter Syndrome: Analysis of a Global Federated Research Network

Abstract Introduction Klinefelter syndrome (KS) is a genetic condition in which male born with an extra X-chromosome and one of the on-label indications for testosterone replacement therapy (TRT). The prevalence deficiency men KS difficult to predict not well described literature. Furthermore, there no previous literature detailing rates TRT prescription diagnosed KS. Objective We aimed determine hypogonadism using large, federated research database. hypothesized that are undertreated due combination factors including poor understanding this population neurocognitive issues leading delay seeking treatment hypogonadism. Methods queried TriNetX, multicenter electronic health record database, identify all diagnosis (ICD-10-CM Q98.4) excluding prior or more than 20 years ago. Descriptive analysis on associated comorbidities demographic characteristics was performed. then filtered initial cohort find who received laboratory measurement level day later. Prevalence determined as defined by < 300 ng/dl. primary outcome study any following forms later medication codes: testosterone, 17-phenylpropionate, enanthate, cypionate, undecanoate. Rates were both hypogonadal subgroup. Results There 5,437 total A 1,581 level, 1,113 (70.4%) whom hypogonadal. Mean group 354 ng/dL [50 – 658]. Of found be hypogonadal, only 657 (59.0%) given TRT. Conclusions This first evaluate prescribing habits In retrospective study, under-prescribed Further studies needed corroborate these findings barriers receiving care population. Disclosure No